Time to ditch HDL-C as a measure of HDL function?

Waist-to-height ratio (WHtR) and triglyceride to HDL-C ratio (TG/HDL-c) as predictors of cardiometabolic risk.

INTRODUCTION The excessive concentration of fat in the abdominal region is related to a higher risk of developing cardiovascular disease (CVD). Studies have been performed to identify simple and effective indicators of abdominal obesity and associated cardiometabolic risk through the use of simple parameters such as anthropometric and biochemical measures. The Triglyceride / High-density Lipopr...

HDL Function: Redefining the HDL Hypothesis for the 21 Century

HDL as a treatment target.

Editor–in–Chief, The Journal of Clinical Lipidology, Charles Howard Candler Professor of Medicine Emeritus, Emory University School of Medicine, 1670 Clairmont Road, Atlanta, GA 30033, USA (Dr. Brown); Director of Lipoprotein and Atherosclerosis, Medstar Research Institute, Washington, DC, USA (Dr. Brewer); Professor of Medicine & Director of Preventive Cardiology & Lipid Clinic, University of ...

Evaluation of non-HDL-c and total cholesterol: HDL-c ratio as cumulative marker of cardiovascular risk in diabetes mellitus.

BACKGROUND Cardiovascular disease (CVD), is the primary cause of morbidity and mortality in patients with diabetes and have approximately--two to four times higher CVD rate than adult without diabetes. Low density lipoprotein cholesterol (LDL-C) is primarily used as the marker of cardiovascular risk in diabetes despite its several limitations. Although several newer markers of CVD are emerging,...

Enhanced HDL Functionality in Small HDL Species Produced Upon Remodeling of HDL by Reconstituted HDL, CSL112

RATIONALE CSL112, human apolipoprotein A-I (apoA-I) reconstituted with phosphatidylcholine, is known to cause a dramatic rise in small high-density lipoprotein (HDL). OBJECTIVE To explore the mechanisms by which the formation of small HDL particles is induced by CSL112. METHODS AND RESULTS Infusion of CSL112 into humans caused elevation of 2 small diameter HDL fractions and 1 large diameter...